Etiological Structure, Clinical and Epidemiological Characteristics of Infections Transmitted by Ixodic Ticks in the Sverdlovsk Region at the Present Stage

Relevance . The Sverdlovsk region is a highly endemic territory for infections transmitted by ixodic ticks. possibilities of laboratory diagnostics tick–borne in the routine practice clinician today are limited mainly testing blood serum antibodies to tick-borne encephalitis virus (TBE virus) and Lyme disease (LD) pathogens – Borrelia burgdorferi sensu lato complex, therefore, among currently TBE LD registered. In case negative results above infections, diagnosis may remain unknown. Aims To study etiological structure ticks at present stage, as well characterize epidemiological clinical features course detected conditions combination natural foci. Materials methods included 227 patients undergoing inpatient or outpatient treatment during epidemic season tick activity 2021 (June-August) LLS MO "New Hospital" (Urban Center Natural Focal Infections). histories (epidemiological, indicators) were studied from each patient, material (blood) was examined prospectively retrospectively using molecular biological (PCR) serological (ELISA, planar protein biochip) methods. Results discussion During study, six diseases identified patients: TBE, (erythematous nonerythematous forms), miyamotoi (BMD), human granulocytic anaplasmosis (HGA), monocytic ehrlichiosis (HME), "Viral fever arthropods" (VFTA). Among patients, proportion with monoinfection 49,5%, mixed infection 50,5%. Additional studies conducted us specific PCR presence DNA rickettsia causative agent Q-fever gave results. general characteristics vector-borne mechanism, prevalence groups middle-aged elderly people, largest number cases any occurred Yekaterinburg its surroundings, all duration bite most did not exceed one day; there differences sex, incubation period. Clinical symptoms similar, except erythematous form (the erythema migrans byte site tick), because vast majority had infectious syndrome; indicators varied. Confirmation based on complex application research Conclusions modern represented only LD, but also new our country, such BMD, HGA, HME, while high various combinations has been revealed.